A critical assessment on the reproductive
EPA is inconsistent in characterizing the strongest evidence of reproductive toxicity. As indicated on page of the draft, EPA considered those studies supportive of a point of departure to derive an RfV based on some of these strengths. The limitations include use of a single exposure level, insufficient study details, excessive maternal toxicity, and lack of conformity with current EPA and Organisation for Economic Co-operation and Development OECD regulatory testing guidelines because of when the studies were conducted. In addition to being well conducted, both Tinston and Carney et al. CNS depression appears to be more accurate on the basis of the symptoms described. Nevertheless, both studies were limited by potential selection bias and small sample sizes and did not adequately address early fetal loss. Special attention will be paid to the endocrine toxicity mode-of-action. After publication of this study, it was discovered that some members of the control population were misclassified and were actually exposed, so the analyses in the paper are no longer valid. Next course dates will be announced here later. That discrepancy was difficult to resolve and may be spurious. An increase in small-for-gestational-age cases was observed in children born to older women and women who had a history of fetal loss, but little effect was observed in other segments of the population. In general, the committee did not consider the draft section on adverse reproductive and developmental outcomes to be balanced in the presentation or critique of studies. Information on pharmacokinetics, mechanisms, or known properties of the chemical class may also strengthen the evidence. The second study examined total fertility in the wives of dry-cleaners by using standardized fertility ratios; this study was uninformative in that it was too small to evaluate fertility patterns.
EPA also considered potential male-mediated effects of tetrachloroethylene Eskenazi et al. For example, only two studies of the reproductive toxicity of tetrachloroethylene are described, and many of the developmental-toxicity studies described have limitations.
Particular focus will be given to identification of critical effects, extrapolation to humans and sensitive groups, application of assessment factors and allocation of health-based guidance values.
Stating whether tetrachloroethylene can be identified as a developmental toxicant or a reproductive toxicant according to the criteria in the EPA developmental-toxicity risk-assessment guidelines EPA and reproductive-toxicity risk-assessment guidelines EPA would be helpful to risk managers and others and would help to identify data gaps.
In addition, tetrachloroethylene and TCA produce different types of developmental toxicity. And a critical task to achieving that equity is increasing the status of women globally — through better education, economic opportunities, and access to reproductive healthcare.
In general, the committee did not consider the draft section on adverse reproductive and developmental outcomes to be balanced in the presentation or critique of studies. According to the EPA risk-assessment guidelines, the increased resorptions in the Schwetz et al. Standardized test guidelines of reproductive and endocrine disrupting effects will be covered. For example, there is sufficient evidence to identify tetrachloroethylene as a developmental toxicant in experimental animals on the basis of the results of Carney et al. EPA did not comment on the relatively high concentrations of TCA required to cause developmental toxicity compared with the concentration expected to result from metabolism of tetrachloroethylene in vivo or on whether this could account for the difference in the type of developmental effects that result from tetrachloroethylene exposure. It would provide a context for the descriptions of individual studies and would be helpful in characterizing the animal developmental-toxicity and reproductive-toxicity data available for hazard identification and dose-response evaluation. In addition to being well conducted, both Tinston and Carney et al. The Intergovernmental Panel on Climate Change report — the scary global climate update from October — devoted a large portion of a chapter to that riddle. They provide limited but supportive evidence of an association between tetrachloroethylene exposure and spontaneous abortion. The behavioral effects reported by Szakmary et al.
Pairs that ultimately produced surviving offspring were less aggressive and engaged in more nest activity than pairs that were not productive. Michelle Erenberg, the cofounder and executive director of Lift Louisiana, a reproductive rights organization in New Orleans, points out that lack of access to reproductive healthcare services makes women, children, and families generally more vulnerable in a host of different ways, from economic disparities to lack of employment opportunities.
Reproductive health assessment questionnaire
In the studies by Schwetz et al. Nevertheless, both studies were limited by potential selection bias and small sample sizes and did not adequately address early fetal loss. The behavior of newly paired birds may provide information that could be used to predict future reproductive success. There is a mathematical reality about carbon emissions, Liverman adds: More people means more emissions, especially in high-consumption countries like the U. The draft IRIS assessment considered the evidence on reproductive effects of tetrachloroethylene to be limited but cited spontaneous abortion as the outcome for which the evidence of an association with tetrachloroethylene was strongest on the basis of results in three papers Kyyronen et al. For example, only two studies of the reproductive toxicity of tetrachloroethylene are described, and many of the developmental-toxicity studies described have limitations. EPA provides no summary information on the reproductive toxicity of tetrachloroethylene even though data are available from a well-conducted two-generation reproduction study Tinston Information on pharmacokinetics, mechanisms, or known properties of the chemical class may also strengthen the evidence. Finally, the discrepancy in emphasizing spontaneous abortion as the outcome with the strongest evidence of an association with tetrachloroethylene exposure in Chapter 4 and intrauterine growth retardation in Chapter 6 suggests that the evidence on reproductive outcomes was not carefully evaluated. Course application Information on application procedure to the next course will be available later. Without a separate discussion of each, it is difficult to identify conflicting data and data gaps and to assess whether there is sufficient evidence of toxicity for each end point according to the criteria in the EPA , guidelines.
Attention will be paid to interpretation possibilities and evaluation of data from different test systems, handling of uncertainties and data gaps, and other problems in health risk assessment of reproductive toxicity and endocrine disruption.
The behavior of newly paired birds may provide information that could be used to predict future reproductive success. According to the EPA risk-assessment guidelines, the increased resorptions in the Schwetz et al.
Connecting reproductive rights and climate change can be fraught, to say the least.
based on 36 review